Introductory Biomedical Imaging

Case Study 1

Case Study 1: Veterinary Examination

Veterinarians use the full complement of medical imaging techniques to diagnose and treat animals. Projection radiography is used to identify broken bones, tumors, and foreign objects, among others. Ultrasound is used to study soft tissue, including cardiac function, and to guide biopsy needles, among others. More complicated procedures involving expensive equipment and/or expert analysis are typically performed at specialty clinics. Associated techniques can include computed tomography (CT), nuclear imaging (e.g., PET), and magnetic resonance imaging (MRI). Veterinary uses of these advanced techniques track their uses on humans. Moreover, like medical doctors, veterinary specialists receive special training and certification in these techniques (see, e.g.,https://acvr.org).

This case study explores the use of x-rays and ultrasound during a visit to the veterinarian. The authors' cat, Ranger, was being treated for small cell lymphoma. He had been receiving treatment for a few years but had seemingly started to relapse. The specialist took X-ray and ultrasound images, since the disease had affected the gut, and ran various blood panels. The conclusion was that Ranger’s condition had deteriorated, leading to adjustments in his medications. This Case Study focuses on the imaging portion of the examination.

X-Ray Examination

Veterinary diagnostic radiographic studies of the thorax and/or abdomen typically include at least two projections: (1) a right (R) or left (L) lateral view, and (2) a ventrodorsal (VD) or dorsoventral (DV) view. Right and left lateral views are taken with the animal lying on its right (R) or left (L) side, respectively. Ventrodorsal and dorsoventral views are taken with the animal lying on its back (VD) or stomach (DV), respectively. Radiopaque markers (e.g., “L” and “R”) are placed near the animal to distinguish the views.

Projection radiographs lack depth information because the intensity of each point in the image is a superposition of all structures along a given straight-line X-ray trajectory through the body. However, by taking images along at least two orthogonal directions (e.g., R or L AND VD or DV), the veterinarian can obtain three-dimensional information from the two-dimensional images. For example, the pairs of superimposed ribs visible in the accompanying L and R radiographs are visible as separate left and right ribs in the VD view. Taking both L and R views, or both VD and DV views, can yield additional information.

The radiologist stated that the Ranger's radiographs were largely normal for an older cat. In particular, they show arthritic changes in both elbows and the middle back. However, the images did not show any abnormalities in the lungs and only mild, if any, enlargement of the heart. Overall, these were good results.

Ranger's Radiographs

Left View
Right View
Ventrodorsal View

Ultrasound Examination

Veterinary ultrasound examinations of the thorax and/or abdomen typically include a number of views selected to assess the health and function of internal organs. Unlike with radiography, the images do not include the lungs because ultrasound reflects off the outer boundaries of the lungs, making it difficult to see inner structures.

The veterinarian generated a series of images showing different organs and substructures by changing the position and orientation of the ultrasound transducer. The images were collected in a defined order, which is repeated from patient to patient, ensuring that nothing is missed. In Ranger's case, the sonographer collected about twenty images during an examination that lasted about fifteen minutes.

Ultrasound Image Acquisition

The sonographer stated that Ranger's ultrasound images were largely normal for an older cat. In particular, they show changes in the kidneys that are commonly noted in geriatric cats and that reflect a risk for the development of chronic kidney disease. However, the images did not show any significant abnormalities in Ranger's stomach, intestines, and associated lymph nodes. Nonetheless, the results did not rule out recurrence of Ranger's small cell lymphoma.

Ranger's Ultrasound Images